We love it when people ask that!
Our joking response: “Tell us where the native speakers of ‘international English’ grow up, and we’ll provide you with their English.”
On a more serious note: we know all the tricks of the trade and how to avoid upsetting various readers. We have both US and UK speakers of English, so we know all the faux pas, the vocab to avoid, and dangerous double entendres.
Ultimately, however, you have to choose one type of spelling: UK or US.